Background: Preterm labor is a serious cause of neonatal morbidity and\nmortality. This study aims to compare the effects of nifedipine, Magnesium\nsulfate and ritodrine as tocolytic drugs in patients presented with threatened\npreterm labor. Patients and Methods: The current study was randomized\ncontrolled trial conducted in Sohag Teaching Hospital between November\n2015 and September 2016. Patients were divided into: Group A: 101 patients\nreceived intravenous ritodrine infusion; Group B: 101 patients received\nintravenous magnesium sulfate; Group C: 101 patients received oral nifedipine.\nDifferent maternal and neonatal outcomes were assessed. Results: The\nbaseline criteria were homogenous among the study groups with no statistically\nsignificant differences. There is no difference between each other group\nregarding the need for additional tocolysis or the rate of recurrence of labour\npains. Nifedipine was associated with the least length of hospital stay. There is\nno difference between all groups regarding the rate of preterm delivery before\nfull steroid dose (p > 0.05). However, nifedipine group was the least one in the\nrate of occurrence of preterm delivery within 7 days from initiation of tocolytic\ntherapy. Similarly, nifedipine group was associated with higher gestational age\nat delivery and significant prolongation of pregnancy than the other groups.\nConclusion: Oral nifedipine use was associated with less recurrence of labor\npains, less need for additional tocolysis, less duration of hospital stay, and more\npatient satisfaction in patients with threatened preterm labour.
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